On the Recoverability of Causal Relations from Bulk Gene Expression Data

arXiv:2606.00568v1 Announce Type: new Abstract: Bulk gene expression profiling, which aggregates pooled RNA across cells within a biological sample, remains important in the single-cell era because it is typically less noisy, more sensitive, and more cost-effective than single-cell assays. Accordingly, a growing body of computational methods seeks to recover causal relations among genes from bulk expression data. However, aggregation is a lossy, non-invertible coarsening of the underlying cellular system, and it remains unclear whether and under what conditions causal relations are recoverable

Source: arXiv cs.LG — read the full report at the original publisher.

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