Going back to February there was a bug report around the xHCI controller dieing on resume from s2idle when using an AMD Ryzen AI Max+ "Strix Halo" Framework Desktop. In turn all USB devices behind the xHCI controller are lost on resume, but unbinding and binding the driver can restore the functionality without a reboot. After months of back and forth communication, it looks like a solution has been figured out and comes down to a nuance of the PCI spec with needing a brief wait...
Source: Phoronix — read the full report at the original publisher.