
arXiv:2605.10181v2 Announce Type: replace-cross Abstract: Out-of-distribution (OOD) detection is essential for building reliable AI systems, as models that produce outputs for invalid inputs cannot be trusted. Although deep learning (DL) is often assumed to outperform traditional machine learning (ML), medical imaging data are typically acquired under standardized protocols, leading to relatively constrained image variability in OOD detection tasks. This motivates a direct comparison between ML and DL approaches in this setting. The two approaches are evaluated on open datasets comprising over
This research addresses the critical need for reliable AI systems by focusing on out-of-distribution detection, a key challenge in deploying AI in real-world, sensitive applications like medical imaging.
Ensuring AI models are trustworthy and do not produce erroneous outputs for unseen data is fundamental for broader AI adoption and safety, particularly in high-stakes fields.
This comparative study directly informs the ongoing debate and architectural choices for OOD detection, potentially guiding development towards more robust and context-appropriate AI deployments.
- · AI safety and reliability researchers
- · Medical AI development
- · Deep learning frameworks (if they show superiority)
- · Unreliable AI systems
- · Traditional machine learning (if proven inferior in specific OOD tasks)
Improved reliability and trustworthiness of AI systems in specialized domains like medical imaging.
Accelerated deployment of AI in regulated industries where OOD detection is a prerequisite for approval.
Shift in AI research focus towards more robust and explainable OOD detection methods, impacting general AI architecture design.
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Read at arXiv cs.AI