SIGNALAI·Jun 2, 2026, 4:00 AMSignal75Medium term

CLSP-REQA: A Real-Time Quality-Aware Closed-Loop Seizure Prediction Framework with Mamba-BiLSTM and Confidence-Gated Intervention

Source: arXiv cs.LG

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CLSP-REQA: A Real-Time Quality-Aware Closed-Loop Seizure Prediction Framework with Mamba-BiLSTM and Confidence-Gated Intervention

arXiv:2606.00074v1 Announce Type: cross Abstract: Reliable seizure prediction is a prerequisite for closed-loop neurostimulation therapy, yet existing methods rarely account for the variability in EEG signal quality encountered in real-world deployment, and the overwhelming majority adopt non-strict evaluation protocols that overestimate generalisation performance. We propose CLSP-REQA (Closed-Loop Seizure Prediction with Real-time EEG Quality Assessment), a unified framework that embeds a lightweight signal quality estimator directly within the prediction pipeline. A Real-time EEG Quality Ass

Why this matters
Why now

The continuous advancements in AI and machine learning, coupled with the increasing demand for reliable real-time medical interventions, are driving innovations in closed-loop neurostimulation.

Why it’s important

This development enhances the reliability and effectiveness of seizure prediction systems, moving closer to practical and safer personalized medical devices, potentially improving quality of life for epilepsy patients.

What changes

The integration of real-time EEG quality assessment directly into seizure prediction pipelines addresses a critical real-world limitation, significantly improving the accuracy and trustworthiness of such systems.

Winners
  • · Epilepsy patients
  • · Medical device manufacturers
  • · Neuroscience researchers
  • · AI healthcare providers
Losers
  • · Developers of non-strict evaluation protocols
  • · Traditional EEG monitoring solutions
Second-order effects
Direct

Improved seizure prediction leads to more effective and less disruptive neurostimulation therapies.

Second

Increased adoption of closed-loop neurostimulation technologies in clinical settings and patient homes.

Third

Enhanced trust in AI-driven medical devices paves the way for further integration of AI into critical healthcare functions.

Editorial confidence: 90 / 100 · Structural impact: 60 / 100
Original report

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Read at arXiv cs.LG
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