arXiv:2605.00074v2 Announce Type: replace-cross Abstract: DNA-synthesis providers screen incoming orders by searching the requested sequence against curated hazard lists. We show that this baseline collapses to a 100% false-flag rate when the hazardous sequence comes from a taxonomic family absent from the reference set: under Conformal Risk Control's certified miss-rate constraint, a low-discrimination signal forces the threshold below the entire test-benign mass. We compose three signals derived from a synthesis order's public annotation: $k$-mer Jaccard similarity to known toxins, the trimm
The increasing sophistication of DNA synthesis paired with AI for hazard screening highlights the growing need for robust safety protocols as the biotech industry matures.
This research addresses a critical vulnerability in DNA synthesis screening, which underpins the safe development of synthetic biology and prevents misuse.
The proposed CRC-Screen system introduces certified hazard screening with improved resilience against taxonomic shifts, enhancing the safety and reliability of DNA synthesis.
- · Synthetic biology companies
- · Biosecurity agencies
- · DNA synthesis providers
- · Malicious actors attempting to synthesize hazardous DNA
More reliable and less error-prone screening of DNA synthesis orders.
Increased trust and accelerated innovation within the synthetic biology sector due to enhanced safety measures.
Potential for new regulatory standards or industry best practices to adopt certified screening methods, impacting global biosecurity policies.
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Read at arXiv cs.AI