SIGNALAI·Jun 19, 2026, 4:00 AMSignal75Medium term

Modeling Day-Long ECG Signals to Predict Heart Failure Risk with Explainable AI

Source: arXiv cs.LG

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Modeling Day-Long ECG Signals to Predict Heart Failure Risk with Explainable AI

arXiv:2601.00014v2 Announce Type: replace-cross Abstract: Heart failure (HF) affects 11.8% of adults aged 65 and older, reducing quality of life and longevity. Preventing HF can reduce morbidity and mortality. We hypothesized that artificial intelligence (AI) applied to 24-hour single-lead electrocardiogram (ECG) data could predict the risk of HF within five years. To research this, the Technion-Leumit Holter ECG (TLHE) dataset, including 69,663 recordings from 47,729 patients, collected over 20 years was used. Our deep learning model, DeepHHF, trained on 24-hour ECG recordings, achieved an ar

Why this matters
Why now

Advances in AI, particularly deep learning, combined with increasing access to large medical datasets like the Technion-Leumit Holter ECG (TLHE), are making such predictive models feasible and robust.

Why it’s important

Early and accurate prediction of heart failure risk using non-invasive, widely available methods like ECGs can significantly improve patient outcomes, reduce healthcare costs, and extend healthy lifespans.

What changes

The capability to predict heart failure risk years in advance using AI-analyzed ECG data shifts medical practice towards proactive intervention and preventive care for a major chronic disease.

Winners
  • · AI healthcare providers
  • · Cardiovascular diagnostics companies
  • · Patients at risk of heart failure
  • · Digital health platforms
Losers
  • · Traditional diagnostic methods
  • · Hospitals burdened by late-stage HF admissions
Second-order effects
Direct

Widespread adoption of AI-powered ECG analysis for preventive cardiovascular health screening.

Second

Increased demand for, and investment in, large, diverse medical datasets and explainable AI in healthcare.

Third

Potential for AI to become a standard tool for population-level health risk assessment across various chronic conditions, influencing public health policy and insurance models.

Editorial confidence: 90 / 100 · Structural impact: 60 / 100
Original report

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Read at arXiv cs.LG
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